کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1965197 1538648 2015 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Interleukin-1β in intervertebral disk degeneration
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Interleukin-1β in intervertebral disk degeneration
چکیده انگلیسی


• IL-1β is highly expressed in degenerative IVD tissues and cells.
• IL-1β facilitates multiple pathological processes involving IDD.
• Inhibition of IL-1β has therapeutic potential for alleviating IDD.

Intervertebral disk degeneration (IDD) is the most common diagnosis in patients with low back pain, a main cause of musculoskeletal disability in the world. Interleukin-1 (IL-1) β is the most important member of the IL-1 family, and has a strong pro-inflammatory activity by stimulating the secretion of multiple pro-inflammatory mediators. IL-1β is highly expressed in degenerative intervertebral disk (IVD) tissues and cells, and it has been shown to be involved in multiple pathological processes during disk degeneration, including inflammatory responses, matrix destruction, angiogenesis and innervation, cellular apoptosis, oxidative stress and cellular senescence. However, inhibition of IL-1β is found to promote extracellular matrix (ECM) repair and protect against disk regeneration. In this review, after a brief description of IL-1β signaling, we mainly focus on the expression profiles, roles and therapeutic potential of IL-1β in IDD. A better understanding will help develop novel IL-1β-based therapeutic interventions for degenerative disk disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinica Chimica Acta - Volume 450, 23 October 2015, Pages 262–272
نویسندگان
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