کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1965510 1538670 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
ABCG5/ABCG8 in cholesterol excretion and atherosclerosis
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
ABCG5/ABCG8 in cholesterol excretion and atherosclerosis
چکیده انگلیسی


• The ABCG5/ABCG8 heterodimer promotes cholesterol removal from the body.
• LXR is the major positive regulator of ABCG5 and ABCG8 expression.
• The ABCG5/ABCG8 heterodimer plays a critical role in atherosclerosis.

Cholesterol is essential for the growth and function of all mammalian cells, but abnormally increased blood cholesterol is a major risk factor for atherosclerotic cardiovascular disease. ATP-binding cassette (ABC) transporters G5 (ABCG5) and G8 (ABCG8) form an obligate heterodimer that limits intestinal absorption and facilitates biliary secretion of cholesterol and phytosterols. Consistent with their function, ABCG5 and ABCG8 are located on the apical membrane of enterocytes and hepatocytes. Liver X receptor is the major positive regulator of ABCG5 and ABCG8 expression. Mutations in either of the two genes cause sitosterolemia, a condition in which cholesterol and plant sterols accumulate in the circulation leading to premature cardiovascular disease. Overexpression of ABCG5 and ABCG8 in mice retards diet-induced atherosclerosis because of reduced circulating and hepatic cholesterol. In the current review, we summarize recent developments and propose a future framework that provides new perspectives on the regulation of cholesterol metabolism and treatment of atherosclerotic cardiovascular disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinica Chimica Acta - Volume 428, 20 January 2014, Pages 82–88
نویسندگان
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