کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1965567 1538678 2013 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A vision for better health: Mass spectrometry imaging for clinical diagnostics
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
A vision for better health: Mass spectrometry imaging for clinical diagnostics
چکیده انگلیسی

BackgroundMass spectrometry imaging (MSI) is a powerful tool that grants the ability to investigate a broad mass range of molecules from small molecules to large proteins by creating detailed distribution maps of selected compounds. Its usefulness in biomarker discovery towards clinical applications has obtained success by correlating the molecular expression of tissues acquired from MSI with well-established histology.ResultsTo date, MSI has demonstrated its versatility in clinical applications, such as biomarker diagnostics of different diseases, prognostics of disease severities and metabolic response to drug treatment, etc. These studies have provided significant insight in clinical studies over the years and current technical advances are further facilitating the improvement of this field. Although the underlying concept is simple, factors such as choice of ionization method, sample preparation, instrumentation and data analysis must be taken into account for successful applications of MSI. Herein, we briefly reviewed these key elements yet focused on the clinical applications of MSI that cannot be addressed by other means.ConclusionsChallenges and future perspectives in this field are also discussed to conclude that the ever-growing applications with continuous development of this powerful analytical tool will lead to a better understanding of the biology of diseases and improvements in clinical diagnostics.


► Current advances of MSI and its emerging clinical applications are reviewed.
► Novel clinical applications of MSI are reviewed.
► Future perspectives of MSI in the clinical setting are discussed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinica Chimica Acta - Volume 420, May 2013, Pages 11–22
نویسندگان
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