کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1966003 1538709 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Assessment of inflammatory markers in patients with community-acquired pneumonia — Influence of antimicrobial pre-treatment: Results from the German competence network CAPNETZ
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Assessment of inflammatory markers in patients with community-acquired pneumonia — Influence of antimicrobial pre-treatment: Results from the German competence network CAPNETZ
چکیده انگلیسی

BackgroundThere is almost no data about the influence of antimicrobial pre-treatment (APT) on levels of inflammatory markers in community acquired pneumonia (CAP). The aim of this study was to investigate the influence of APT on inflammatory markers in CAP.Methods991 hospitalized patients (64.3 ± 17.6 years, 61% male) with CAP were enrolled. In all patients procalcitonin (PCT), C-reactive protein (CRP), and leukocyte count (WBC) were determined. Patients were followed-up for 28 days for survival.Results232 patients (23.4%) had APT, 759 had no APT. Patients without APT had significantly higher levels of PCT and WBC but not of CRP compared to those with APT. In patients without APT, survivors compared to non-survivors had lower values of PCT (0.20 ng/mL; 0.02–169.10 vs. 0.83 ng/mL; 0.04–516.30, p < 0.0001), WBC (12.4 × 109/L; 1.3–49.9 vs. 14.9 × 109/L; 3.7–34.5, p = 0.047) and CRP (107.0 mg/mL; 0.3–567.0 vs. 143.5 mg/mL; 5.0–589.0, p = 0.006). However, in patients with APT, the values of PCT, WBC and CRP were not significantly different in survivors and non-survivors. Cox regression analysis confirmed that PCT, CRP and WBC were predictive for 28 day mortality in patients without APT but not in those with APT.ConclusionsPCT and WBC but not CRP levels are higher in patients without APT compared to those with APT. PCT, CRP and WBC are predictive for 28 days mortality exclusively in patients without APT. Interpretation of inflammatory parameters has to take into account possible APT.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinica Chimica Acta - Volume 411, Issues 23–24, 14 December 2010, Pages 1929–1934
نویسندگان
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