کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1966313 1538729 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Asymmetric dimethylarginine predicts outcome and time of stay in hospital in patients attending an internal medicine emergency room
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Asymmetric dimethylarginine predicts outcome and time of stay in hospital in patients attending an internal medicine emergency room
چکیده انگلیسی

IntroductionFor patients attending the emergency room (ER) valid diagnostic criteria which identify patients at risk for an adverse outcome are needed. We investigated the predictive value of asymmetric dimethylarginine (ADMA) in unselected patients attending an internal medicine ER regarding outcome of the patients and duration of stay in the hospital.Patients and methodsPatients (n = 417) attending the ER were classified according to their primary diagnosis. Routine laboratory tests were performed and ADMA was determined. Patients were followed for a primary endpoint of in hospital death and complicated outcome.ResultsADMA levels were highest in patients with a cancer-related diagnosis (0.76 (0.63–0.93) µmol/L) and in patients with a cardiovascular diagnosis (0.69 (0.60–0.80) µmol/L; p < 0.001). Overall, we found increasing proportions of patients experiencing the primary end point over the quartiles of ADMA (4.6%, 8.2%, 9.6%, and 15.8%; p = 0.007). ADMA had the highest predictive value for the primary endpoint in patients with cardiovascular disease (odds ratio 19.4; p = 0.029). In a Cox proportional hazard model ADMA was an independent predictor of the length of hospitalization (hazard ratio 2.0 (95% CI: 1.3–3.3); p = 0.006) in the entire cohort.ConclusionWe conclude that ADMA independently predicts future complications and hospitalization in patients attending an ER.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinica Chimica Acta - Volume 401, Issues 1–2, March 2009, Pages 20–24
نویسندگان
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