کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1966452 1538722 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Genetic determinants of extracellular magnesium concentration: Analysis of multiple candidate genes, and evidence for association with the estrogen receptor α (ESR1) locus
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Genetic determinants of extracellular magnesium concentration: Analysis of multiple candidate genes, and evidence for association with the estrogen receptor α (ESR1) locus
چکیده انگلیسی

BackgroundSerum magnesium concentration is a quantitative trait with substantial heritability. Although the pool of candidate genes continues to grow, only the histocompatibility locus has been associated with magnesium levels. To explore other possibilities, we targeted 6 candidate genes physiologically relevant to magnesium metabolism.MethodsWe studied a large cohort (n = 471) derived from a well-characterized population of healthy Caucasian women 18 to 35 years. Total serum magnesium and calcium were measured by atomic absorption spectrophotometry (aaMg & aaCa). Genomic DNA was amplified and SNPs in candidate genes (CASR, VDR, ESR1, CLDN16, EGF1, TRPM6) genotyped by routine methods.ResultsWe found a significant association between estrogen receptor α (ESR1) polymorphisms, PvuII and XbaI, and magnesium (r = − 0.116, p = 0.012 and r = − 0.126, p = 0.006, respectively). Stratifying by PvuII genotype (P/p alleles), the mean adjusted total magnesium (aaMg) concentration was significantly higher (p = 0.01) in the pp group (0.823 ± 0.005 mmol/l, n = 130) than in PP homozygotes (0.805 ± 0.006 mmol/l, n = 70), and the mean in Pp heterozygotes was intermediate (0.810 ± 0.005 mmol/l, n = 180). No significant associations were observed with the other candidate genes tested.ConclusionsThe significant association between magnesium and ESR1 polymorphisms supports previous studies linking physiologic changes in serum magnesium to estrogen status.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinica Chimica Acta - Volume 409, Issues 1–2, 3 November 2009, Pages 28–32
نویسندگان
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