کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1966471 1538722 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Genetic polymorphism of the tissue inhibitor of metalloproteinase-1 is associated with an increased risk of endometrial cancer
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Genetic polymorphism of the tissue inhibitor of metalloproteinase-1 is associated with an increased risk of endometrial cancer
چکیده انگلیسی

BackgroundTissue inhibitors of metalloproteinases (TIMPs) are a family of multifunctional proteins known to possess a broad range of biological activities involved in tumorgenesis and mRNA expression of TIMP family members has been shown to be upregulated in numerous cancers and correlates with clinical outcomes. We investigated the association of TIMP-1 and TIMP-2 gene polymorphism with risk of endometrial cancer.MethodsIn the present case–control study, we enrolled a total of 118 endometrial cancer patients confirmed by histopathology and 229 unrelated healthy individuals. Polymorphism for TIMP-1 (_372C > T) and TIMP-2 (_418G > C and _303C > T) genes was genotyped by PCR-RFLP.ResultsFrequency of TIMP-1_372C/C genotype and 372-C allele differed significantly between patients with endometrial cancer (38.1% and 56.4% respectively) and healthy individuals (22.7% and 44.1% respectively). Individuals with TIMP-1_372 C/C genotype were at higher risk of endometrial cancer (OR = 2.37; 95%CI: 1.33–4.22). Stratification analysis showed that individuals with TIMP-1_372 C/C genotype were at increased risk for endometrioid (OR = 2.46; 95% CI 1.34–4.53) and low stage (stages I–II) endometrial cancer (OR = 3.24; 95% CI 1.22–4.13). However, no significant differences in TIMP-2_418G > C and TIMP-2_303C > T genotypes were observed between endometrial carcinoma cases and controls.ConclusionIndividuals with TIMP-1_372C/C genotype were at significantly higher risk of endometrial cancer.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinica Chimica Acta - Volume 409, Issues 1–2, 3 November 2009, Pages 127–131
نویسندگان
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