کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1966682 1538727 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Prevalence of serum antibodies to TORCH among women before pregnancy or in the early period of pregnancy in Beijing
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Prevalence of serum antibodies to TORCH among women before pregnancy or in the early period of pregnancy in Beijing
چکیده انگلیسی

BackgroundThe primary infection of Toxoplasma gondii (TOX), rubella virus (RV), cytomegalovirus (CMV), or herpes simplex virus (HSV), abbreviated as TORCH, remains a major problem in the pregnant women in China today.MethodsWe analyzed the performance of a novel chemiluminesent immunoassay (CLIA) for anti-TORCH IgM and IgG detection then analyzed the prevalence of TORCH infection among 4692 women at childbearing age in Beijing, China.ResultsThe functional sensitivity of detecting anti-TOX IgM, anti-RV IgM, anti-CMV IgM and anti-HSV (types 1 and 2) IgM were 1.4, 3.2, 1.0 AU/ml and 0.5 index, respectively. The within-assay and the total CVs were both < 10%, and recoveries of these assays ranged from 90–110%. High concentration of hemoglobin, lipids and bilirubin in sample did not affect the results. The infective rate of TORCH was 17.2%, with the highest positive rate of anti-HSV IgM. Within anti-TORCH IgG, anti-CMV IgG had the highest infective rate, 92.5%.ConclusionsThe infective rate of TORCH was fairly high among women before pregnancy or in the early period of pregnancy in Beijing. Entirely new approaches to prevention and treatment of congenital TORCH infection are necessary.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinica Chimica Acta - Volume 403, Issues 1–2, May 2009, Pages 212–215
نویسندگان
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