کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1967150 1538736 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Elevated serum levels of intercellular adhesion molecule ICAM-1 in Pseudoxanthoma elasticum
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Elevated serum levels of intercellular adhesion molecule ICAM-1 in Pseudoxanthoma elasticum
چکیده انگلیسی

BackgroundPseudoxanthoma elasticum (PXE, OMIM 177850 and 264800) is a rare heritable disorder predominantly affecting the skin, the eyes and the vascular system. The disease is caused by mutations in the ABCC6 gene and is characterized by calcification and extracellular matrix remodeling, including alterations of the vessel walls. Here, we investigated the cell adhesion molecules ICAM-1 in PXE patients.MethodsSoluble ICAM-1 was determined in 58 non-consanguineous PXE patients by quantitative sandwich enzyme immunoassay. The allelic frequencies of the ICAM-1 variant p.K469E were analyzed in patients and age- and sex-matched controls.ResultsSoluble ICAM-1 levels were significantly elevated in male and female PXE patients (p < 0.02 and p < 0.001, respectively). In addition, the ICAM-1 concentration correlated with the ABCC6 gene status of the PXE patients. The ICAM variant p.K469E genotypes were not different in PXE patients and age- and sex-matched controls.ConclusionsOur data show for the first time increased ICAM-1 concentrations in PXE patients, potentially due to the chronic oxidative stress and elevated protease activity followed by extracellular matrix remodeling which have been previously observed in PXE patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinica Chimica Acta - Volume 394, Issues 1–2, August 2008, Pages 54–58
نویسندگان
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