کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1967398 1538742 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Association of eNOS Glu298Asp gene polymorphism with essential hypertension in Asian Indians
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Association of eNOS Glu298Asp gene polymorphism with essential hypertension in Asian Indians
چکیده انگلیسی

BackgroundSeveral reports suggested association between the T allele of the endothelial nitric oxide synthase gene polymorphism (eNOS) Glu298Asp (G → T at nucleotide 894, exon 7) with essential hypertension (EHT). Findings, however are not uniform. In this case–control study, we determined the prevalence and distribution of the above polymorphism and their relationship with the disease to elucidate the association of this polymorphism with the risk and pathophysiology of EHT in the Asian Indians and significance of T allele in this context.MethodsTwo hundred normal controls and 226 patients with EHT from Delhi and surrounding areas were recruited for the investigation. Venous blood samples were used for genotyping. Genotyping was done by PCR-RFLP.ResultsThe data suggested higher prevalence of GT + TT genotypes in patients as compared to the controls and association of T allele with EHT [p < 0.001, odds ratio at 95% CI, 2.10 (1.34-3.28)].ConclusionsAsian Indians of this region with T allele may be at higher risk of EHT.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinica Chimica Acta - Volume 387, Issues 1–2, January 2008, Pages 80–83
نویسندگان
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