The role of protein kinases in pancreatic carcinogenesis

BackgroundPancreatic cancer is a devastating disease with a very poor prognosis.MethodsProtein kinases are aberrantly expressed in pancreatic ductal adenocarcinoma as analyzed by microarray-based expression analysis and have an impact for pancreatic cancer. Many regulatory proteins have an impact on cancer progression similar to the kinases. The list contains several regulators of kinases derived from the cell cycle control or the mitogen-activated protein (MAP)-kinase pathway.ConclusionBoth signalling pathways are essential for tumor progression and pancreatic ductal adenocarcinoma (PDAC) malignancy.