کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1969073 | 1059759 | 2013 | 10 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Proteomics advancements in fetomaternal medicine Proteomics advancements in fetomaternal medicine](/preview/png/1969073.png)
The study of interactions between genes and their environment, thus of molecules that form the “functional genome”, has been greatly enhanced throughout the course of post-genomic era by the expansion of the omic technologies. Proteomic technologies and mass spectrometry in particular, form a well-armored strategy towards high-throughput simultaneous analysis of thousands of proteins and protein-related molecules. Proteomics as in the past, are still currently offering novel perspectives in the understanding over the pathophysiology of malicious conditions as well as in the development of molecular-targeted therapeutics against them. This review examines the offerings of proteomics research over the unique physiological phenomenon of pregnancy and its related complications, which affect both maternal and perinatal health.
► Major mass spectrometric methods currently used in proteomic analyses are discussed.
► The application of proteomics in fetomaternal medicine is summarized.
► Pregnancy-related biological materials used for proteomic analyses are discussed.
► Available biomarkers for diagnosis of pregnancy-related complications are presented.
► The potential of proteomics for the non-invasive prenatal diagnosis is presented.
Journal: Clinical Biochemistry - Volume 46, Issue 6, April 2013, Pages 487–496