کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1969358 | 1538891 | 2011 | 8 صفحه PDF | دانلود رایگان |
ObjectivesTo determine age and gender specific reference intervals for bone markers.Design and methodsMorning blood samples were collected after overnight fast from 356 healthy children (6 to 18 year-old) for the determination of bone marker levels, PTH and vitamin D3. Multiple regression analysis was done to assess the effect of factors that could influence the bone marker levels; the central 95% reference interval and their 90% CI were calculated.ResultsAfter excluding samples when BMI-z —scores were <−2 or >+2, both vitamin D3 and PTH levels were abnormal and from children who used steroids the remainder were partitioned using Tanner stage based chronological age. As expected the reference intervals show a significant variation with age and gender. All the bone marker levels, except total alkaline phosphatase, were significantly higher in puberty with vitamin D3 > 75 nmol/L.ConclusionVitamin D status, age and gender are important for establishing reference intervals of bone markers in healthy children.
Journal: Clinical Biochemistry - Volume 44, Issues 10–11, July 2011, Pages 771–778