کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
197013 | 459867 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Simultaneously electrogenerated diene and dienophile: A unique access to novel polyfunctionalized 1,4-benzoxazine derivatives as neuroprotective agents
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
مهندسی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Simultaneously electrogenerated diene and dienophile: A unique access to novel polyfunctionalized 1,4-benzoxazine derivatives as neuroprotective agents Simultaneously electrogenerated diene and dienophile: A unique access to novel polyfunctionalized 1,4-benzoxazine derivatives as neuroprotective agents](/preview/png/197013.png)
چکیده انگلیسی
New insights into the scope of a multistep one-pot electrochemical synthesis of polyfunctionalized 2-alkylamino-1,4-benzoxazine derivatives are delineated. This cascade sequence, wherein both cycloaddition partners are generated in situ, at room temperature, under metal-free conditions, should be useful to generate libraries of heterocycles which constitute the molecular framework of medicinally relevant compounds. In this respect, 2-alkylamino-1,4-benzoxazine derivatives proved to be potent neuroprotective agents in vitro, on immortalized HT22 hippocampal cell cultures, and in vivo, in an animal model mimicking the cerebral palsy in human newborns.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Electrochimica Acta - Volume 50, Issues 25–26, 5 September 2005, Pages 4902–4910
Journal: Electrochimica Acta - Volume 50, Issues 25–26, 5 September 2005, Pages 4902–4910
نویسندگان
Estelle Blattes, Maurice-Bernard Fleury, Martine Largeron,