کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
197021 | 459867 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Integrated compact biocompatible hydrogel-based amperometric sensing device for easy screening of drugs involved in nitric oxide production by adherent cultured cells
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
مهندسی شیمی (عمومی)
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چکیده انگلیسی
We report in this study on the first use a compact biocompatible hydrogel-based electrochemical sensing device for the examination of NO production from adherently growing cells. The conception assessment is tested here in the case of C6 glioma cells. The main body of the integrated device is made of three-planar disc (1 mm of diameter each) array electrode with a mounted acrylic reservoir, and the resulting chamber served as the electrochemical cell. The ionically conducting biocompatible hydrogel membrane is then deposited on the planar surface of the substrate on which the examined NO-releasing cells are cultured. Such a device allows having a living cell-based device for an easy screening of drugs for NO production and/or inhibition.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Electrochimica Acta - Volume 50, Issues 25–26, 5 September 2005, Pages 4988–4994
Journal: Electrochimica Acta - Volume 50, Issues 25–26, 5 September 2005, Pages 4988–4994
نویسندگان
Corinne Wartelle, Wolfgang Schuhmann, Andrea Blöchl, Fethi Bedioui,