کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1970298 | 1538917 | 2007 | 7 صفحه PDF | دانلود رایگان |
Objectives:Procalcitonin (PCT) and interleukin-6 (IL-6) are established markers of tissue inflammation and injury. The aim of the present study was to investigate the possible correlation of PCT and IL-6 with liver metastasis.Design and methods:The study consisted of fifteen healthy controls (group A), twenty-one patients with solid tumors without metastases (group B), eleven patients with liver metastasis only (group C) and eleven patients with generalized metastatic disease (group D).Results:Serum PCT levels were significantly increased in group D compared to groups A (p < 0.001) and B (p = 0.004), but no difference was observed in PCT levels between groups C and B or C and D. IL-6 serum levels were markedly elevated in group C compared to group A (p < 0.001) or to groups B (p < 0.001) and D (p = 0.02). A positive correlation was observed between PCT and IL-6 serum levels (r = 0.357, p = 0.019).Conclusions:PCT levels are related to disease stage in cancer patients, whereas IL-6 concentration seems to be a more specific marker of liver metastasis.
Journal: Clinical Biochemistry - Volume 40, Issues 5–6, March 2007, Pages 336–342