کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1971681 1059879 2006 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Total plasma homocysteine values among elderly subjects: Findings from the Maracaibo Aging Study
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Total plasma homocysteine values among elderly subjects: Findings from the Maracaibo Aging Study
چکیده انگلیسی

Objectives:The present study generated baseline data for total homocysteine (tHcy) in elderly Caribbeans of Hispanic ancestry, residing in Venezuela, their country of origin.Design and methods:2106 participants in the Maracaibo Aging Study (MAS), older than 55 years, underwent standardized clinical and laboratory assessments, including measurement of plasma tHcy levels, folate, and vitamin B12 in fasting samples.Results:tHcy concentration in the healthy, normative group ranged from 4.1 to 31.8 μmol/L, with a median of 11.5 ± 4.7 μmol/L. tHcy level increased with age, was significantly higher in men than in women, and exhibited inverse correlations with folate and vitamin B12.Conclusions:tHcy levels of the MAS participants were generally higher than levels previously reported for community-dwelling elderly populations from other countries. The normative centile curves for tHcy can be used in disease risk analysis for this population, and possibly for other Hispanic populations residing in the Caribbean.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Biochemistry - Volume 39, Issue 10, October 2006, Pages 1007–1015
نویسندگان
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