کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1977108 1539274 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Physiological responses of carp (Cyprinus carpio L.) to dietary exposure to zearalenone (ZEN)
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Physiological responses of carp (Cyprinus carpio L.) to dietary exposure to zearalenone (ZEN)
چکیده انگلیسی

Zearalenone (ZEN) is a frequent contaminant of animal feeds, but systemic effects on fish and possible metabolic costs have not yet been investigated. In order to fill this gap a feeding trial with juvenile carp was conducted. The fish were fed ZEN-contaminated diets at three concentrations (low: 332 μg kg− 1, medium: 621 μg kg− 1, and high: 797 μg kg− 1 final feed, respectively) for four weeks. Possible reversible effects of ZEN were evaluated by feeding an additional group with the mycotoxin for four weeks period and the uncontaminated diet for further two weeks. After that possible ZEN effects on enzyme activities in kidney, spleen, liver and muscle tissue were investigated to get an organism-wide aspect of ZEN effects. Most organs appeared to (over)compensate ZEN effects during the exposure to this mycotoxin, which caused metabolic costs. Oxygen consumption increased in fish treated with the two higher ZEN concentrations via the diet. The differences between the treatments persisted also after the recovery phase of two weeks. Thus, the present study provided evidence of effects of ZEN on carbohydrate metabolism, lipid peroxidation in organs and metabolic oxygen demand. This is the first evidence for increased metabolic costs in a fish species due to exposure to the mycotoxin ZEN.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology - Volume 188, October 2016, Pages 52–59
نویسندگان
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