کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1980415 1061854 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evidence for upregulated repair of oxidatively induced DNA damage in human colorectal cancer
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Evidence for upregulated repair of oxidatively induced DNA damage in human colorectal cancer
چکیده انگلیسی
► We report on oxidatively induced DNA damage in colorectal cancer. ► We measured the levels of major DNA base lesions in cancerous colorectal tissues and their surrounding normal tissues of patients. ► We used mass spectrometry and found significantly lower levels of DNA lesions in cancerous tissues than those in non-cancerous tissues. ► Our results suggest that repair of oxidative DNA damage may be up-regulated in colorectal tumors, compared to normal colorectal tissues. ► The type of DNA base lesions identified suggests the upregulation of both base excision and nucleotide excision pathways.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: DNA Repair - Volume 10, Issue 11, 10 November 2011, Pages 1114-1120
نویسندگان
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