کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1980960 | 1061890 | 2007 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
RecA-DNA filament topology: The overlooked alternative of an unconventional syn–syn duplex intermediate
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
The helical filaments of RecA protein mediate strand exchange for homologous recombination, but the paths of the interacting DNAs have yet to be determined. Although this interaction is commonly limited to three strands, it is reasoned here that the intrinsic symmetry relationships of quadruplex topology are superior in explaining a range of observations. In particular, this topology suggests the potential of post-exchange base pairing in the unorthodox configuration of syn–syn glycosidic bonds between the nucleotide bases and the pentose rings in the sugar–phosphate backbone, which would transiently be stabilized by the external scaffolding of the RecA protein filament.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: DNA Repair - Volume 6, Issue 5, 1 May 2007, Pages 669–675
Journal: DNA Repair - Volume 6, Issue 5, 1 May 2007, Pages 669–675
نویسندگان
Richard Egel,