کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1981873 1539422 2012 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
In silico prediction of a disease-associated STIL mutant and its affect on the recruitment of centromere protein J (CENPJ)
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
In silico prediction of a disease-associated STIL mutant and its affect on the recruitment of centromere protein J (CENPJ)
چکیده انگلیسی
▸ A computational platform was used for pathogenic allele prediction. ▸ The Rs147744459 allele of STIL was predicted to be most associated with disease. ▸ The R242C mutation was shown to disrupt the binding affinity of STIL for CENPJ. ▸ The 3D conformation of STIL protein was drastically affected by this mutation. ▸ Loss of H-bond formation affected protein stability in the STIL R242C mutant.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Open Bio - Volume 2, 2012, Pages 285-293
نویسندگان
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