RNAi knockdown of dRNaseZ, the Drosophila homolog of ELAC2, impairs growth of mitotic and endoreplicating tissues

► dRNaseZ is a JH inducible gene that encodes a tRNA endonuclease. ► The genetic knockdown of dRNaseZ impairs tRNA processing, hinders cell growth and proliferation. ► Mutant animals are defective in both larval growth and molting.