کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1984187 1539947 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The 5′ adenosine monophosphate-activated protein kinase: Regulating the ebb and flow of cellular energetics
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
The 5′ adenosine monophosphate-activated protein kinase: Regulating the ebb and flow of cellular energetics
چکیده انگلیسی

The 5′ adenosine monophosphate-activated protein kinase (AMPK) is a heterotrimeric, evolutionary conserved enzyme which has emerged as a critical regulator of skeletal muscle cellular bioenergetics. AMPK is activated by both chemical (adipokines) and mechanical (stretch, contraction) stimuli leading to metabolic changes within muscle cells that include increased fatty acid oxidation, glucose uptake and glycolysis, as well as the stimulation and regulation of mitochondrial biogenesis. Collectively these acute responses and chronic adaptations act to reduce cellular disturbances, resulting in tighter metabolic control and maintenance of energy homeostasis. This brief review will describe the structure, function and activation of AMPK in skeletal muscle and how this ubiquitous molecule may be a plausible target for the treatment of several lifestyle-related metabolic disorders.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The International Journal of Biochemistry & Cell Biology - Volume 41, Issue 12, December 2009, Pages 2360–2363
نویسندگان
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