کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1984691 1539986 2006 21 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Animal models of type 2 diabetes with reduced pancreatic β-cell mass
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Animal models of type 2 diabetes with reduced pancreatic β-cell mass
چکیده انگلیسی

Type 2 diabetes is increasingly viewed as a disease of insulin deficiency due not only to intrinsic pancreatic β-cell dysfunction but also to reduction of β-cell mass. It is likely that, in diabetes-prone subjects, the regulated β-cell turnover that adapts cell mass to body's insulin requirements is impaired, presumably on a genetic basis. We still have a limited knowledge of how and when this derangement occurs and what might be the most effective therapeutic strategy to preserve β-cell mass. The animal models of type 2 diabetes with reduced β-cell mass described in this review can be extremely helpful (a) to have insight into the mechanisms underlying the defective growth or accelerated loss of β-cells leading to the β-cell mass reduction; (b) to investigate in prospective studies the mechanisms of compensatory adaptation and subsequent failure of a reduced β-cell mass. Furthermore, these models are of invaluable importance to test the effectiveness of potential therapeutic agents that either stimulate β-cell growth or inhibit β-cell death.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The International Journal of Biochemistry & Cell Biology - Volume 38, Issues 5–6, May–June 2006, Pages 873–893
نویسندگان
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