The role of thymidine phosphorylase and uridine phosphorylase in (fluoro)pyrimidine metabolism in peripheral blood mononuclear cells

In conclusion, PBMC were relatively insensitive to 5′dFUrd, and the natural substrates dThd and Urd were preferentially converted by TP and UP, respectively. TP and UP were both responsible for converting 5′dFUrd/5FU into 5FU/FUrd, respectively.