کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1988071 1540305 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Curdlan microspheres. Synthesis, characterization and interaction with proteins (enzymes, vaccines)
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Curdlan microspheres. Synthesis, characterization and interaction with proteins (enzymes, vaccines)
چکیده انگلیسی

Microparticles of curdlan, synthesized through crosslinking with epichlorohydrin in organic suspension media, were chemically modified with the aim of introducing strongly and/or weakly acidic anionic and palmitoyl hydrophobic groups. Microparticles of both curdlan and curdlan derivatives were physico-chemically characterized. Study of the interaction with enzymes, such as lysozyme, and vaccines, such as tetanus anatoxin, showed a co-operative protein retention effect, induced by electrostatic and hydrophobic forces. The results of the in vitro release studies on support–protein complexes recommend them as potential controlled release systems.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Biological Macromolecules - Volume 44, Issue 3, 1 April 2009, Pages 215–221
نویسندگان
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