Developmental expression of cellular prion protein and apoptotic molecules in the rat cerebellum: Effects of platinum compounds

► Cellular prion protein (PrPc) could have a neuroprotective role against apoptosis. ► Studies were performed on cerebellar vermis sections after Pt compounds treatment. ► Co-localization of PrPc, Bcl-2 and Bax arose from differentiating Purkinje cells. ► PrPc, together with Bcl-2 action, limited cytotoxicity during postnatal development.