کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1990561 | 1540752 | 2006 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Apoptosis induction by γ-tocotrienol in human hepatoma Hep3B cells
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
We evaluated the antitumor activity of tocotrienol (T3) on human hepatoma Hep3B cells. At first, we examined the effect of T3 on the proliferation of human hepatoma Hep3B cells and found that γ-T3 inhibited cell proliferation at lower concentrations and shorter treatment times than α-T3. Then, we examined the effect of γ-T3 apoptosis induction and found that γ-T3 induced poly (ADP-ribose) polymerase (PARP) cleavage and stimulated a rise in caspase-3 activity. In addition, γ-T3 stimulated a rise in caspase-8 and caspase-9 activities. We also found that γ-T3-induced apoptotic cell death was accompanied by up-regulation of Bax and a rise in the fragments of Bid and caspase-8. These data indicate that γ-T3 induced apoptosis in Hep3B cells and that caspase-8 and caspase-9 were involved in apoptosis induction. Moreover, these results suggest that Bax and Bid regulated apoptosis induction by γ-T3.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Nutritional Biochemistry - Volume 17, Issue 10, October 2006, Pages 672-676
Journal: The Journal of Nutritional Biochemistry - Volume 17, Issue 10, October 2006, Pages 672-676
نویسندگان
Midori Sakai, Masaaki Okabe, Hirofumi Tachibana, Koji Yamada,