کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1991639 1541021 2012 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Progesterone inhibition of neuronal calcium signaling underlies aspects of progesterone-mediated neuroprotection
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Progesterone inhibition of neuronal calcium signaling underlies aspects of progesterone-mediated neuroprotection
چکیده انگلیسی

Progesterone is being utilized as a therapeutic means to ameliorate neuron loss and cognitive dysfunction following traumatic brain injury. Although there have been numerous attempts to determine the means by which progesterone exerts neuroprotective effects, studies describing the underlying molecular mechanisms are lacking. What has become clear, however, is the notion that progesterone can thwart several physiological processes that are detrimental to neuron function and survival, including inflammation, edema, demyelination and excitotoxicity. One clue regarding the means by which progesterone has restorative value comes from the notion that these aforementioned biological processes all share the common theme of eliciting pronounced increases in intracellular calcium. Thus, we propose the hypothesis that progesterone regulation of calcium signaling underlies its ability to mitigate these cellular insults, ultimately leading to neuroprotection. Further, we describe recent findings that indicate neuroprotection is achieved via progesterone block of voltage-gated calcium channels, although additional outcomes may arise from blockade of various other ion channels and neurotransmitter receptors.This article is part of a Special Issue entitled ‘Neurosteroids’.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Steroid Biochemistry and Molecular Biology - Volume 131, Issues 1–2, August 2012, Pages 30–36
نویسندگان
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