کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1991799 1541030 2011 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Expression of hexose-6-phosphate dehydrogenase in rat tissues
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Expression of hexose-6-phosphate dehydrogenase in rat tissues
چکیده انگلیسی

Hexose-6-phosphate dehydrogenase (H6PD) is the main NADPH generating enzyme in the lumen of the endoplasmic reticulum. H6PD is regarded as an ancillary enzyme in prereceptorial glucocorticoid activation and probably acts as a nutrient sensor and as a prosurvival factor. H6PD expression was determined in a variety of rat and human tissues by detecting mRNA and protein levels, and by measuring its dehydrogenase and lactonase activities. It was found that H6PD was present in all investigated tissues; both expression and activity remained within an order of magnitude. Correlation was found between the dehydrogenase activity and protein or mRNA levels. The results confirmed the supposed housekeeping feature of the enzyme.


► Distribution of hexose-6-phosphate dehydrogenase (H6PD) was studied.
► H6PD mRNA, protein and activity were present in all investigated rat tissues.
► The results confirm the supposed housekeeping feature of H6PD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Steroid Biochemistry and Molecular Biology - Volume 126, Issues 3–5, September 2011, Pages 57–64
نویسندگان
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