کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1992365 | 1541076 | 2007 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Clinical implication of estrogen-related receptor (ERR) expression in ovarian cancers
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Clinical implication of estrogen-related receptor (ERR) expression in ovarian cancers Clinical implication of estrogen-related receptor (ERR) expression in ovarian cancers](/preview/png/1992365.png)
چکیده انگلیسی
The expression of estrogen receptor (ER)α and ERβ mRNAs did not show any specific manner according to clinical backgrounds in ovarian cancers. On the other hand, the levels of estrogen-related receptor (ERR)α mRNA increased with clinical stages regardless of histopathological types in ovarian cancers. However, ERRβ and ERRγ mRNA levels were extremely low to determine reliably. ERRα can bind to the steroid receptor coactivator family without any ligands, and drive transcription activity of the target genes. The manner of ERR and ER gene expressions might show an independent usage of common cofactors. It is speculated that the up regulation of ERRα might be related to advancement of ovarian cancers regardless of plausible interaction via cofactors regulated by ERs. Although ERRα is not directly related to growth of ovarian cancer, ERRα is a candidate for prognostic factors for ovarian cancer.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Steroid Biochemistry and Molecular Biology - Volume 104, Issues 3â5, May 2007, Pages 301-304
Journal: The Journal of Steroid Biochemistry and Molecular Biology - Volume 104, Issues 3â5, May 2007, Pages 301-304
نویسندگان
Jiro Fujimoto, Syed Mahfuzul Alam, Israt Jahan, Eriko Sato, Hideki Sakaguchi, Teruhiko Tamaya,