کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1992891 1541092 2006 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
New anabolic steroid illegally used in cattle—structure elucidation of 19-norchlorotestosterone acetate metabolites in bovine urine
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
New anabolic steroid illegally used in cattle—structure elucidation of 19-norchlorotestosterone acetate metabolites in bovine urine
چکیده انگلیسی

4-Chloro-estr-4-en-17-ol-3-one, trivially named 19-norclostebol acetate or 4-chloro-19-nortestosterone acetate (NClTA), has been identified on the European black market in the late 1990s for possible use in breeding animals. After oral and subcutaneous administration of NClTA to bovine, urine samples were collected over a period of three weeks, and chemical structure of main excreted urinary metabolites was determined. After oral administration, the most abundant metabolites were mainly reduced as 4-chloro-19-norandrostan-3ξ-ol-17-one and 4-chloro-19-norandrostan-3ξ,17ξ-diol. They were identified until 1 week after administration. Following subcutaneous injection, 4-chloro-19-norandrostan-3ξ-ol-17-one was again of major abundance, but so were 4-chloro-19-norandrost-4-ene-3ξ,17ξ-diol and 4-chloro-19-norandrost-4-en-3ξ-ol-17-one. They were detected at least 3 weeks after administration. Whatever the route of administration, metabolites were found mainly glucurono-conjugated; the only exception was metabolite 4-chloro-19-norandrostan-3ξ-ol-17-one which was identified both in the sulpho- and glucurono-fractions.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Steroid Biochemistry and Molecular Biology - Volume 98, Issue 1, January 2006, Pages 78–89
نویسندگان
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