کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1993060 | 1541087 | 2006 | 6 صفحه PDF | دانلود رایگان |

Previous in vitro experiments showed that both, Taenia crassiceps and Taenia solium cysticerci have the ability to metabolize exogenous androstenedione to testosterone. Here we evaluate on the capacity of both cysticerci to synthesize several sex steroid hormones, using different hormonal precursors. Experiments using thin layer chromatography (TLC) showed that both cysticerci were able to produce 3H-hydroxyprogesterone, 3H-androstenedione and 3H-testosterone when 3H-progesterone was used as the precursor. They also synthesized 3H-androstenediol and 3H-testosterone when 3H-dehydroepiandrosterone was the precursor. In addition, both cysticerci interconverted 3H-estradiol and 3H-estrone. These results, strongly suggest the presence and activity of the Δ4 and Δ5 steroid pathway enzymes, 3β-hydroxysteroid dehydrogenase/Δ5-4 isomerase-like enzyme (3β-HSD), that converts androstenediol into testosterone; and the 17β-hydroxysteroid dehydrogenase that interconverts estradiol and estrone, in both types of cysticerci.
Journal: The Journal of Steroid Biochemistry and Molecular Biology - Volume 99, Issues 4–5, June 2006, Pages 203–208