کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1993264 1541242 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Modifications of collagen-based biomaterials with immobilized growth factors or peptides
ترجمه فارسی عنوان
تغییرات مواد بیولوژیکی مبتنی بر کلاژن با فاکتورهای رشد بی حرکتی یا پپتیدهای
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی


• We modified collagen sponges with immobilized growth factors or peptides.
• Chitosan-collagen hydrogel was modified with immobilized QHREDGS peptide.
• Immobilization efficiency, release rate, and physical property were characterized.
• We described in vitro assays to test the modified biomaterials with cell culture.

In order to provide an instructive microenvironment to facilitate cellular behaviors and tissue regeneration, biomaterials can be modified by immobilizing growth factors or peptides. We describe here our procedure for modification of collagen-based biomaterials, both porous scaffolds and hydrogel systems, with growth factors or peptides by covalent immobilization. Characterizations of the modified biomaterials (immobilization efficiency, release profile, morphology, mechanical strength, and rheology) and in vitro testing with cells are also discussed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Methods - Volume 84, August 2015, Pages 44–52
نویسندگان
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