کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1994064 1064731 2010 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Optimization of in vivo high-resolution DTI of non-human primates on a 3T human scanner
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Optimization of in vivo high-resolution DTI of non-human primates on a 3T human scanner
چکیده انگلیسی

Magnetic resonance (MR) diffusion tensor imaging (DTI) has emerged as a unique technique to reveal small anatomical structures of brain by characterizing the diffusion process of water molecules within an image voxel. Combined with fiber tractography techniques, DTI can be further used to reveal white matter fibers and connectivity in the brain non-invasively. The non-human primate brain study provides important supplemental means for human brain exploration since the two species share close anatomical and functional similarities. There is therefore increasing interest in in vivo non-human primate DTI studies. However, several technical challenges need to be addressed to perform non-human primate brain DTI and fiber tractography. We have established an imaging protocol together with a post-acquisition procedure for high-resolution in vivo non-human primate DTI studies using a 3T human clinical scanner. Data acquired with this procedure is appropriate for accurate diffusion tensor quantification and fiber tractography, and is accessible within an acceptable scan time. We investigated in detail the effects of spatial resolution and SNR on diffusion tensor-derived quantities and fiber tractography. Our results should be of general utility for implementation of in vivo non-human primate DTI studies.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Methods - Volume 50, Issue 3, March 2010, Pages 205–213
نویسندگان
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