کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1995189 | 1064956 | 2008 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Quantification of in vivo tumor invasion and vascularization by computerized image analysis
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Quantification of in vivo tumor invasion and vascularization by computerized image analysis Quantification of in vivo tumor invasion and vascularization by computerized image analysis](/preview/png/1995189.png)
چکیده انگلیسی
The matrix-inserted surface transplantation model is an in vivo assay used to analyse the kinetics of tumor-vessel interactions during different stages of skin carcinoma progression. This system allows the study of host-tumor interface, i.e. penetration of tumor cells into normal host tissue as well as infiltration of normal host cells into the tumor. In the present study, image analysis algorithms for processing and quantifying the extent of such migratory and tissue remodeling events are presented. The proposed method is non-parametric and its originality lies in its particularity to take into account the specific geometry of tumor-host interface. This methodology is validated by evaluating the contribution of matrix metalloproteases (MMPs) in skin carcinoma invasion and vascularization through pharmacological and genetic approaches.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microvascular Research - Volume 75, Issue 2, March 2008, Pages 169-178
Journal: Microvascular Research - Volume 75, Issue 2, March 2008, Pages 169-178
نویسندگان
S. Blacher, M. Jost, L. Melen-Lamalle, L.R. Lund, J. Romer, J.M. Foidart, A. Noël,