کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1995253 | 1064959 | 2008 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Dose response of angiogenesis to basic fibroblast growth factor in rat corneal pocket assay: II. Numerical simulations
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Dose response of angiogenesis to basic fibroblast growth factor in rat corneal pocket assay: II. Numerical simulations Dose response of angiogenesis to basic fibroblast growth factor in rat corneal pocket assay: II. Numerical simulations](/preview/png/1995253.png)
چکیده انگلیسی
Angiogenesis involves interactions among various molecules and cells. To understand the complexity of interactions, we developed a mathematical model to numerically simulate angiogenesis induced by basic fibroblast growth factor (bFGF) in the corneal pocket assay. The model considered interstitial transport of bFGF, cellular uptake of bFGF, and dynamics of vessel growth. The model was validated by comparing simulated vascular networks, induced by bFGF at three different doses: 5Â ng, 15Â ng, and 50Â ng, with experimental data obtained in the first part of the study, in terms of migration distance of vascular network, total vessel length, and number of vessels. The model was also used to simulate growth dynamics of vascular networks as well as spatial and temporal distribution of bFGF, which could not be measured experimentally. Taken together, results of the study suggested that the coupling between diffusion and cellular uptake of bFGF was critical for determining structures of vascular networks and that the mathematical model was appropriate for simulation of angiogenesis in the cornea.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microvascular Research - Volume 75, Issue 1, January 2008, Pages 16-24
Journal: Microvascular Research - Volume 75, Issue 1, January 2008, Pages 16-24
نویسندگان
Sheng Tong, Fan Yuan,