کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1995357 | 1064964 | 2007 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Interaction between liposomes and RBC in microvessels in vivo
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Liposomes are phospholipid vesicles that can serve as carriers of biologically active agents in vitro and in vivo. Here, we describe the movement of liposomes suspended with blood flowing in capillaries. Liposomes were coated with a polymer to extend their lifespan in rat mesenteric blood vessels and detected by fluorescent staining. Liposome activity was observed by intravital microscopy using a high-speed camera system at 5 and 60Â min after liposome administration. Liposome velocity was determined using two-dimensional cross-correlation, and blood flow was measured by high-resolution PIV (particle image velocimetry). The results showed that the motion of polymer-coated liposome followed the phase averaged velocity distribution of heartbeats while flowing with red blood cells in microvessels. Liposome particles tend to move toward the near blood vessel wall in the low velocity of blood flow.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microvascular Research - Volume 73, Issue 1, January 2007, Pages 39-47
Journal: Microvascular Research - Volume 73, Issue 1, January 2007, Pages 39-47
نویسندگان
Jae Hong Jeong, Yasuhiko Sugii, Motomu Minamiyama, Hirofumi Takeuchi, Koji Okamoto,