Structural Basis for NADH/NAD+ Redox Sensing by a Rex Family Repressor

▸ A structural comparison of Rex in the NAD+/DNA-bound, apo-, and NADH-bound states ▸ A rigid-body rotation of Rex subunits permits DNA binding after NADH dissociation ▸ A single NAD+ binds the Rex dimer/DNA complex ▸ A triad of conserved residues are required for NADH/NAD+ sensing by Rex