کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1998052 | 1065641 | 2006 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Inhibition of HIV-1 Gene Expression by a Fragment of hnRNP U Inhibition of HIV-1 Gene Expression by a Fragment of hnRNP U](/preview/png/1998052.png)
SummaryCellular proteins are now appreciated as critically involved in all steps of the human immunodeficiency virus type 1 (HIV-1) life cycle, and disrupting host functions essential for virus replication may provide novel antiviral approaches. Selection from a human complementary DNA (cDNA) library for clones able to induce resistance to infection by recombinant HIV-1 genomes resulted in the identification of a gene fragment that potently restricts HIV-1 activity. The active cDNA encodes an N-terminal fragment of the heterogeneous nuclear ribonuclear protein U (hnRNP U). The gene fragment specifically targets the 3′ long terminal repeat (3′LTR) in the viral mRNA and blocks the cytoplasmic accumulation of HIV-1 mRNAs. The results suggest that HIV-1 requires machinery for the nuclear export of viral mRNAs that can be specifically blocked by an interfering gene.
Journal: - Volume 23, Issue 4, 18 August 2006, Pages 597–605