کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1999066 1065839 2011 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Does a lower carbohydrate protein substitute impact on blood phenylalanine control, growth and appetite in children with PKU?
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Does a lower carbohydrate protein substitute impact on blood phenylalanine control, growth and appetite in children with PKU?
چکیده انگلیسی

BackgroundIn children with phenylketonuria (PKU), it is possible that high carbohydrate protein substitutes may adversely affect blood phenylalanine control. We evaluated if a low carbohydrate, ‘ready-to-drink’ protein substitute would impact on short term blood phenylalanine control, weight and appetite in children with PKU aged 3–10 years.MethodsThis was a 3-part, 5-week randomised, controlled, crossover study in which two different carbohydrate/protein-equivalent ratios in protein substitute [control protein substitute (CPS) median 1:1; trial protein substitute (TPS) 0.5:1] were compared. The effects on feeding behaviour, weight change and phenylalanine concentrations were studied. Fourteen children (12 boys; median age 6.3 y, range 3 to 9.7 y) with PKU on diet were recruited from 2 treatment centres.ResultsPhenylalanine control did not deteriorate with TPS and remained unchanged between pre-study and CPS (p = 0.783). No statistical differences were noted in energy intake between the two study parts. Any changes in weight were similar between the two groups and there was limited change in feeding behaviour.ConclusionThis study suggests that the carbohydrate/protein-equivalent ratio of protein substitutes can be reduced to 0.5:1 with no loss of blood phenylalanine control or adverse effect on weight gain in children with PKU.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Genetics and Metabolism - Volume 104, Supplement, 2011, Pages S64–S67
نویسندگان
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