کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2000462 | 1541611 | 2015 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Nitrate pharmacokinetics: Taking note of the difference
ترجمه فارسی عنوان
فارماکوکینتیک نیترات: با توجه به تفاوت
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
نیتریت، نیترات، فارماکوکینتیک، ورزش،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
It is now recognised that administration of oral nitrate (NO3â), in its various forms, increases the level of nitric oxide (NO) metabolites in the circulation of humans. Its application to modulate physiology and alleviate cardiovascular dysfunction in some patients is now recorded and shows particular promise in hypertension, in modifying platelet activation/aggregation, and in conditions where tissue ischaemia prevails. The potential of oral NO3â to modify exercise/performance via elevation of plasma nitrite concentration ([NO2â]) has been applied across a range of human test systems. Herein we discuss how the choice of NO3â source, route of administration and resulting pharmacokinetics might influence the outcome of physiological measures and potentially contribute to discrepancies in performance trials. There are but a few examples of detailed pharmacokinetic data on which the majority of researchers base their test protocols in different cohorts/settings. We compare and contrast the results of key publications with the aim of highlighting a consensus of our current understanding and critical considerations for those entering the field.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nitric Oxide - Volume 48, 1 August 2015, Pages 44-50
Journal: Nitric Oxide - Volume 48, 1 August 2015, Pages 44-50
نویسندگان
Philip E. James, Gareth R. Willis, Jason D. Allen, Paul G. Winyard, Andrew M. Jones,