کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2005847 1541707 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Antimicrobial peptides: Possible anti-infective agents
ترجمه فارسی عنوان
پپتیدهای ضد میکروبی: عوامل ضد عفونی ممکن است
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی


• Introduction of various anionic antimicrobial peptides (AMPs), which have received little attention as regards their potential application.
• Description of different AMPs that exhibit a wide range of activities against bacteria, virus, fungi, and parasites.
• Explanation of the tools and trends in AMP delivery required for successful therapeutic effects.
• Discussion of AMPs which are under clinical and preclinical development.

Multidrug-resistant bacterial, fungal, viral, and parasitic infections are major health threats. The Infectious Diseases Society of America has expressed concern on the decrease of pharmaceutical companies working on antibiotic research and development. However, small companies, along with academic research institutes, are stepping forward to develop novel therapeutic methods to overcome the present healthcare situation. Among the leading alternatives to current drugs are antimicrobial peptides (AMPs), which are abundantly distributed in nature. AMPs exhibit broad-spectrum activity against a wide variety of bacteria, fungi, viruses, and parasites, and even cancerous cells. They also show potential immunomodulatory properties, and are highly responsive to infectious agents and innate immuno-stimulatory molecules. In recent years, many AMPs have undergone or are undergoing clinical development, and a few are commercially available for topical and other applications. In this review, we outline selected anion and cationic AMPs which are at various stages of development, from preliminary analysis to clinical drug development. Moreover, we also consider current production methods and delivery tools for AMPs, which must be improved for the effective use of these agents.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Peptides - Volume 72, October 2015, Pages 88–94
نویسندگان
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