Molecular determinants of the interaction between human high molecular weight kininogen and Candida albicans cell wall: Identification of kininogen-binding proteins on fungal cell wall and mapping the cell wall-binding regions on kininogen molecule

► Human high molecular weight kininogen binds to Candida albicans cell wall proteins. ► Als3 adhesin belongs to major high molecular weight fungal binders of kininogen. ► Enolase, phosphoglycerate mutase and triosephosphate isomerase also bind kininogen. ► Cell-wall binding region on kininogen comprises residues 479-564 of domains 5 and 6.