کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2012844 | 1541863 | 2014 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Serotonin 1A receptors and sexual behavior in a genetic model of depression
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کلمات کلیدی
5-HT8-OH-DPAT5-HIAA5-HT1A-receptorFSLFRLFlinders resistant lineWAY100635PEL - از PELEjaculation - انزال، خالی شدنIntromission - تعاملSexual behavior - رفتار جنسیSerotonin - سروتونینEjaculation frequency - فرکانس انزالFlinders sensitive line - فلیندرز حساس خطselective serotonin reuptake inhibitors - مهار کننده های بازجذب سروتونین انتخابیSSRI - مهارکنندههای بازجذب سروتونینMount - کوه
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The Flinder Sensitive Line (FSL) is a rat strain that displays distinct behavioral and neurochemical features of major depression. Chronic selective serotonin reuptake inhibitors (SSRIs) are able to reverse these symptoms in FSL rats. It is well known that several abnormalities in the serotonergic system have been found in FSL rats, including increased 5-HT brain tissue levels and reduced 5-HT synthesis. SSRIs are known to exert (part of) their effects by desensitization of the 5-HT1A receptor and FSL rats appear to have lower 5-HT1A receptor densities compared with Flinder Resistant Line (FRL) rats. We therefore studied the sensitivity of this receptor on the sexual behavior performance in both FRL and FSL rats. First, basal sexual performance was studied after saline treatment followed by treatment of two different doses of the 5-HT1A receptor agonist ± 8-OH-DPAT. Finally we measured the effect of a 5-HT1A receptor antagonist to check for specificity of the 5-HT1A receptor activation. Our results show that FSL rats have higher ejaculation frequencies compared with FRL rats which do not fit with a more depressive-like phenotype. Moreover FRL rats are more sensitive to effects of ± 8-OH-DPAT upon EL and IF than FSL rats. The blunted response of FSL rats to the effects of ± 8-OH-DPAT may be due to lower densities of 5-HT1A receptors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology Biochemistry and Behavior - Volume 121, June 2014, Pages 82-87
Journal: Pharmacology Biochemistry and Behavior - Volume 121, June 2014, Pages 82-87
نویسندگان
D. Schijven, V.C. Sousa, J. Roelofs, B. Olivier, J.D.A. Olivier,