کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2012925 1541858 2014 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Serotonin antagonists induce anxiolytic and anxiogenic-like behavior in zebrafish in a receptor-subtype dependent manner
ترجمه فارسی عنوان
آنتاگونیست های سرتونیین رفتار انکسیولیتیک و مشابه آنژیوژنیک را در ماهیان زرافه در یک روش وابسته به گیرنده دریافت می کنند
کلمات کلیدی
ماهی قزل آلا، اضطراب، آنتاگونیست سروتونین، محیط زیست، رفتار - اخلاق
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی


• Effects of different serotonin receptor antagonists are examined in adult zebrafish.
• Serotonin antagonists alter anxiety-like behavior independent of motor function.
• 5-HT1A, 5-HT2, and 5-HT3 receptor antagonists increase anxiety-like behavior.
• 5-HT1B/D receptor antagonists decrease anxiety-like behavior.

Motor function and anxiety-like responses are easily quantifiable in zebrafish, a novel model organism for behavioral pharmacology. Activation of serotonin receptors through the use of selective agonists has been shown to alter anxiety-like behaviors in zebrafish. However, few studies have examined the effect of blockade of specific serotonin receptors. In the current study, we examine the effect of 4 serotonin receptor antagonists selective for 5-HT1A, 5-HT1B/D, 5-HT2, and 5-HT3 receptors on zebrafish motor and anxiety-like responses. Exposure to the receptor antagonists did not change baseline motor responses. However, when placed in a novel environment, zebrafish previously exposed to GR 55562 (5-HT1B/D antagonist) exhibited reduced anxiety-like behavior, whereas zebrafish previously exposed to p-MPPF (5-HT1A antagonist), Ketanserin (5-HT2 antagonist), or Ondasetron (5-HT3 antagonist) exhibited increased anxiety-like behaviors. These results show that drugs developed for mammalian serotonin receptors are efficacious in the zebrafish too, a finding that demonstrates evolutionary conservation of the serotoninergic system. The results also imply that zebrafish may be an appropriate animal model for examining the serotonergic neurotransmitter system in vertebrates.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology Biochemistry and Behavior - Volume 126, November 2014, Pages 170–180
نویسندگان
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