Exposure to alcohol during adolescence alters the aversive and locomotor-activating effects of cocaine in adult rats

► The present study assessed the long-term effects of adolescent alcohol exposure. ► Adolescent alcohol exposure reduced the aversive effects of cocaine in adult rats. ► Adolescent alcohol exposure altered cocaine-induced motor activity. ► Alcohol exposure in adult rats attenuated later cocaine aversions. ► Exposure to alcohol during adolescence may alter cocaine's abuse liability.