The anthraquinone derivative emodin attenuates methamphetamine-induced hyperlocomotion and startle response in rats

► Abnormal EGF/ErbB signaling is implicated in the neuropathology of schizophrenia. ► The anthraquinone derivative emodin inhibits ErbB1 signaling. ► Emodin suppresses hyperlocomotion induced by acute methamphetamine challenge. ► Emodin interferes with acute methamphetamine signaling and behaviors.