کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2013269 | 1067103 | 2008 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Autonomic activation associated with ethanol self-administration in adult female P rats
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کلمات کلیدی
FHPVTADEPADEBAC - LACAlcohol deprivation effect - اثر محرومیت الکلیAlcohol - الکلbpm - بوقلمونStimulation - تحریکanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceContextual conditioning - تهویه مطبوعAutonomic - خودمختاریintraperitoneal - داخل صفاقیCue-Reactivity - سیگنال واکنش پذیرbeats per minute - ضربان در دقیقهHeart rate - ضربان قلبBlood alcohol concentration - غلظت الکل خونActivation - فعال سازیAlcohol-preferring rats - موش های ترجیح دهنده الکلventral tegmental area - ناحیه تگمنتوم شکمی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The present study examined changes in heart rate (HR) prior to and during limited access ethanol drinking in adult female P rats. P rats were implanted with radio-telemetric transmitters to measure HR. Daily testing involved a 90-min pre-test period (water only available) and a subsequent 90-min test period [either water (W) or ethanol available]. After a week of habituation, one ethanol group had access to ethanol for 7Â weeks (CE), and another ethanol group had access for 4Â weeks, was deprived for 2Â weeks and then had access for a final week (DEP). Analyses of HR revealed that CE and DEP rats had significantly higher HR than W rats during test periods that ethanol was present and that DEP rats displayed higher HR during the early test period of the ethanol deprivation interval, as well. These data indicate that ethanol drinking induces HR activation in adult female P rats, and that this activation can be conditioned to the test cage environment, paralleling reports on contextual conditioning and cue-reactivity in alcoholics exposed to alcohol-associated stimuli. Therefore, this behavioral test may prove advantageous in screening pharmacotherapies for reducing craving and relapse, which are associated with cue-reactivity in abstinent alcoholics.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology Biochemistry and Behavior - Volume 91, Issue 2, December 2008, Pages 223-232
Journal: Pharmacology Biochemistry and Behavior - Volume 91, Issue 2, December 2008, Pages 223-232
نویسندگان
Richard L. Bell, Zachary A. Rodd, Jamie E. Toalston, David L. McKinzie, Lawrence Lumeng, Ting-Kai Li, William J. McBride, James M. Murphy,