Time course of the attenuation effect of repeated antipsychotic treatment on prepulse inhibition disruption induced by repeated phencyclidine treatment

► Acute clozapine attenuated the disruptive effect of PCP on prepulse inhibition (PPI). ► Repeated treatment of clozapine maintained its attenuation. ► Repeated risperidone and quetiapine enhanced their attenuation against the PCP-induced PPI deficits. ► Repeated haloperidol and olanzapine treatments were ineffective.